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Related Experiment Videos

Human platelet arginine vasopressin.

S S Nussey, V T Ang, D H Bevan

    Clinical Endocrinology
    |April 1, 1986
    PubMed
    Summary

    Platelets store most circulating arginine vasopressin (AVP), originating from the hypothalamus. This platelet-bound AVP is biologically active and increases with exogenous AVP, hypertonic saline, or smoking.

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    Area of Science:

    • Endocrinology
    • Neuroscience
    • Hematology

    Background:

    • Arginine vasopressin (AVP) is a key hormone regulating water balance and blood pressure.
    • Approximately 90% of circulating AVP is found bound to platelets, suggesting a significant role for platelets in AVP transport or storage.

    Purpose of the Study:

    • To investigate the origin and biological activity of platelet-bound AVP.
    • To examine factors influencing platelet AVP levels, including exogenous AVP administration, endogenous AVP release, and smoking.

    Main Methods:

    • Chromatographic and biological activity assays were used to characterize platelet AVP.
    • Studies involved patients with cranial diabetes insipidus, normal male subjects receiving AVP infusions, subjects undergoing hypertonic saline infusion, and male smokers exposed to cigarette smoke.

    Main Results:

    • Platelet AVP was confirmed to originate in the hypothalamus and is chromatographically identical and biologically active compared to posterior pituitary AVP.
    • Exogenous AVP infusion, hypertonic saline infusion, and smoking all led to significant increases in both plasma and platelet AVP concentrations.
    • Smokers exhibited higher baseline platelet AVP levels than non-smokers, even after prolonged abstinence.

    Conclusions:

    • Platelets serve as a significant reservoir for biologically active arginine vasopressin, with hypothalamic origin.
    • Platelet AVP levels are responsive to changes in plasma AVP, influenced by physiological stimuli and external factors like smoking.

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