Tracking Biomarker Responses to Exercise in Hypertension
Eric Trillaud1,2, Philip Klemmer3, Steven K Malin4,5,6,7
1Department of Medicine, Division of Nephrology, University of Virginia Health System, Charlottesville, VA, USA. eric.trillaud@hotmail.fr.
Current Hypertension Reports
|July 10, 2023
Summary
Physical exercise helps manage hypertension (HTN) and lower blood pressure. Novel biomarkers, including extracellular vesicles (EVs), are emerging to better track exercise responses in HTN patients.
Area of Science:
- Cardiovascular Physiology
- Exercise Science
- Biomarker Discovery
Background:
- Physical exercise is recognized for its role in preventing and managing hypertension (HTN).
- Current understanding of exercise's effects on HTN pathophysiology is incomplete, explaining only about half of the mechanisms.
- Identifying and confirming exercise effectiveness in HTN patients presents challenges.
Purpose of the Study:
- To review conventional and novel biomarkers for tracking responses to exercise in hypertension.
- To highlight the potential of extracellular vesicles (EVs) and microRNAs in understanding exercise therapy for HTN.
Main Methods:
- Review of evolving data on biomarkers related to aerobic fitness, vascular function, oxidative stress, inflammation, and gluco-lipid toxicity.
- Discussion of novel biomarkers, specifically extracellular vesicles (EVs) and microRNAs.
- Exploration of the integrative "cross-talk" between tissues for blood pressure regulation.
Main Results:
- Conventional biomarkers explain only a portion of the pathophysiology of HTN and exercise response.
- Novel biomarkers like EVs and microRNAs offer additional insights into the complex mechanisms of exercise therapy.
- Biomarker studies are crucial for developing more personalized therapies for HTN.
Conclusions:
- A comprehensive understanding of exercise's role in HTN requires both conventional and novel biomarkers.
- Further systematic approaches and randomized controlled trials are needed to validate exercise effectiveness across different conditions.
- Biomarker research promises more specific disease markers and tailored therapeutic strategies for hypertension.
Keywords:
Aerobic exerciseBiochemical biomarkersHypertensionInflammationMyokinesNovel biomarkersOxidative stressResistance exerciseMore Related Videos
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