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Bile acid-induced diarrhoea.

H Fromm, M Malavolti

    Clinics in Gastroenterology
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Bile acid malabsorption causes diarrhoea, with three types identified based on ileum condition and cholecystectomy history. Diagnosis involves history, stool tests, and bile acid breath tests, with cholestyramine being the effective treatment.

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    Area of Science:

    • Gastroenterology
    • Digestive Diseases
    • Clinical Medicine

    Background:

    • Bile acid malabsorption is a recognized cause of diarrhoea.
    • Three distinct types of bile acid malabsorption exist, differing in ileal pathology and clinical presentation.
    • Understanding these types is crucial for accurate diagnosis and management.

    Purpose of the Study:

    • To differentiate and describe the three types of bile acid malabsorption.
    • To outline diagnostic approaches for bile acid diarrhoea.
    • To confirm the efficacy of cholestyramine in treating bile acid diarrhoea.

    Main Methods:

    • Classification of bile acid malabsorption into types I, II, and III based on ileal morphology and clinical history (e.g., cholecystectomy).
    • Assessment of faecal bile acid concentrations and response to cholestyramine.

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  • Diagnostic tools include patient history, stool weight and pH measurement, and bile acid breath tests.

    • Main Results:

    • Type I involves ileal pathology, Type II has a normal ileum (rare), and Type III is associated with cholecystectomy or other GI conditions.
    • Severe bile acid malabsorption is less common in Type III, with limited response to cholestyramine in some cases.
    • Bile acids are unlikely to cause idiopathic diarrhoea.

    Conclusions:

    • Bile acid diarrhoea can be categorized into three types.
    • Diagnosis relies on a combination of clinical assessment and specific tests.
    • Cholestyramine is the primary and highly effective treatment for bile acid diarrhoea.