Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial
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Published on: August 7, 2017
Ken-Ichi Nagakura1,2, Sakura Sato3, Wakako Shinahara4
1Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan.
Insights
Maternal egg consumption during the first five days postpartum did not affect infant egg allergy (EA) development or sensitization by 12 months. This study found no significant difference in EA rates between groups.
Area of Science:
- Allergy and Immunology
- Pediatrics
- Clinical Trials
Background:
- Early infant egg introduction (4-6 months) reduces allergy risk.
- The impact of maternal egg intake at birth on infant egg allergy (EA) is unknown.
Purpose of the Study:
- To investigate maternal egg intake's effect on EA in breastfed infants at 12 months.
- Assessed maternal egg consumption during the first 5 days postpartum.
Main Methods:
- Randomized clinical trial with 380 newborns at 10 Japanese medical facilities.
- Mothers were assigned to consume (MEC) or eliminate eggs (MEE) for 5 days postpartum.
- Primary outcome: EA at 12 months, defined by sensitization and clinical reaction.
Main Results:
- Maternal egg consumption increased egg protein detection in breast milk.
- No significant difference in EA (9.3% vs 7.6%) or egg white sensitization (62.8% vs 58.7%) at 12 months.
- No adverse effects reported.
Conclusions:
- Maternal egg intake in the early neonatal period does not influence EA development or sensitization.
- Findings suggest maternal diet during this critical window may not be a primary factor in infant EA.
- Further research may explore other dietary or environmental factors.
Importance:
Egg introduction in infants at age 4 to 6 months is associated with a lower risk of immunoglobulin E-mediated egg allergy (EA). However, whether their risk of EA at age 12 months is affected by maternal intake of eggs at birth is unknown.
Objective:
To determine the effect of maternal egg intake during the early neonatal period (0-5 days) on the development of EA in breastfed infants at age 12 months.
Design, Setting, And Participants:
This multicenter, single-blind (outcome data evaluators), randomized clinical trial was conducted from December 18, 2017, to May 31, 2021, at 10 medical facilities in Japan. Newborns with at least 1 of 2 parents having an allergic disease were included. Neonates whose mothers had EA or were unable to consume breast milk after the age of 2 days were excluded. Data were analyzed on an intention-to-treat basis.
Interventions:
Newborns were randomized (1:1) to a maternal egg consumption (MEC) group, wherein the mothers consumed 1 whole egg per day during the first 5 days of the neonate's life, and a maternal egg elimination (MEE) group, wherein the mothers eliminated eggs from their diet during the same period.
Main Outcomes And Measures:
The primary outcome was EA at age 12 months. Egg allergy was defined as sensitization to egg white or ovomucoid plus a positive test result in an oral food challenge or an episode of obvious immediate symptoms after egg ingestion.
Results:
Of the 380 newborns included (198 [52.1%] female), 367 (MEC: n = 183; MEE: n = 184) were followed up for 12 months. On days 3 and 4 after delivery, the proportions of neonates with ovalbumin and ovomucoid detection in breast milk were higher in the MEC group than in the MEE group (ovalbumin: 10.7% vs 2.0%; risk ratio [RR], 5.23; 95% CI, 1.56-17.56; ovomucoid: 11.3% vs 2.0%; RR, 5.55; 95% CI, 1.66-18.55). At age 12 months, the MEC and MEE groups did not differ significantly in EA (9.3% vs 7.6%; RR, 1.22; 95% CI, 0.62-2.40) or sensitization to egg white (62.8% vs 58.7%; RR, 1.07; 95% CI, 0.91-1.26). No adverse effects were reported.
Conclusions And Relevance:
In this randomized clinical trial, EA development and sensitization to eggs were unaffected by MEC during the early neonatal period.
Trial Registration:
UMIN Clinical Trials Registry: UMIN000027593.
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