Related Experiment Video

Updated: Jul 24, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.1K

Targeting the Androgen Signaling Axis in Prostate Cancer

Charles Dai1,2,3, Scott M Dehm4,5,6, Nima Sharifi7,8,9,10,11

  • 1Massachusetts General Hospital Cancer Center, Boston, MA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|July 10, 2023
PubMed

Insights

Androgen receptor (AR) signaling drives prostate cancer, but resistance emerges. This review explores AR targeting, resistance mechanisms, and future therapeutic strategies for metastatic prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Urology

Background:

  • Androgen receptor (AR) signaling is fundamental to prostate cancer development and progression.
  • Therapeutic resistance to AR-directed therapies is a significant clinical challenge.
  • Next-generation therapies validate AR signaling's continued importance in both castration-sensitive and castration-resistant prostate cancer.

Purpose of the Study:

  • To review current understanding of AR signaling in prostate cancer.
  • To discuss mechanisms of therapeutic resistance to AR-targeted treatments.
  • To explore emerging strategies for AR targeting in advanced prostate cancer.

Main Methods:

  • Literature review of AR signaling pathways.
  • Analysis of molecular alterations driving resistance.
  • Discussion of current and future AR-directed therapies.

Main Results:

  • AR signaling remains crucial even with resistance, necessitating continued targeting.
  • Diverse resistance mechanisms exist, involving alterations in the androgen signaling axis.
  • New therapeutic options offer promise but do not fully overcome resistance.

Conclusions:

  • Understanding AR signaling and resistance is key to improving outcomes.
  • Further research into resistance mechanisms will inform novel therapeutic approaches.
  • Continued innovation in AR-targeting strategies is essential for treating metastatic prostate cancer.

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