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Updated: Jul 24, 2025
Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses
Published on: September 11, 2023
Biochemical Analysis of Aqueous Humor in an Elderly Patient with Multiple Myeloma Presenting First as Bilateral
Mamta Agarwal1, Mridula Vijayaraghavan2, Bharathselvi Muthuvel3
1Uveitis & Cornea Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.
Purpose:
To study the biochemical analysis of aqueous humor in a patient with multiple myeloma presenting first as chronic uveitis.
Methods:
Observational case report.
Results:
A 63-year-old healthy woman presented with blurred vision in both eyes for 9 months. Slit-lamp examination showed bilateral conjunctival congestion, corneal oedema, and anterior uveitis. Fundus exam revealed normal optic disc with fine retinal folds in the macula. Serum protein electrophoretogram showed a monoclonal M protein band in the gamma globulin region. The bone marrow biopsy revealed hypercellular marrow with trilineage haematopoiesis and the bone marrow aspirate showed clonal plasma cells >10%, confirming the diagnosis of multiple myeloma. Aqueous fluid showed a differential band in electrophoretic profile of aqueous humor protein that on mass spectrometry analysis was strongly suggestive of immunoglobulin band.
Conclusion:
The biochemical analysis of aqueous humor is another diagnostic test to monitor M protein in patients with multiple myeloma.
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