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Asymmetric mitosis contributes to different migratory performance in sister cells
Maurício Tavares Tamborindeguy1, Paola Farias Lorenzatto1, Marcelo Lazzaron Lamers2
1Departamento de Biofísica, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil; Centro de Biotecnologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil.
Experimental Cell Research
|July 10, 2023
Summary
Cell migration capacity differs between daughter cells after mitosis, impacting cancer invasion. This suggests asymmetric cell division, not inheritance, drives varied cell migration and metastasis potential.
Area of Science:
- Cell Biology
- Cancer Research
- Metastasis Studies
Background:
- Cell migration is crucial for tumor spread and metastasis.
- Heterogeneity in cell migration capacity can lead to increased invasion.
- Asymmetric cell division is hypothesized to generate cells with heightened migratory potential.
Purpose of the Study:
- To determine if sister cells exhibit different migratory capacities.
- To investigate if mitosis influences these migratory differences.
- To analyze the heritability of cell migration performance.
Main Methods:
- Time-lapse video microscopy was used to track cell movement.
- Analyzed migration speed, directionality, displacement, and velocity.
- Compared migratory phenotypes, cell area, and polarity between mother-daughter and sister cells across tumor and normal cell lines.
Main Results:
- Daughter cells displayed distinct migratory phenotypes compared to their mother cells.
- Sister cells showed divergent migratory behaviors after a single mitosis.
- Mitosis did not significantly alter cell area or polarity dynamics.
- Cell migration performance was found to be non-heritable.
Conclusions:
- Asymmetric cell division generates daughter cells with varied migratory capacities.
- This heterogeneity in migration performance may significantly contribute to cancer invasion and metastasis.
- Cell migration characteristics are not solely determined by inheritance but influenced by cell division processes.
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