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Insula-cingulate structural and functional connectivity: an ultra-high field MRI study.

Matthew A Cormie1,2, Batu Kaya1,2, Georgia E Hadjis1,2

  • 1Centre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.

Cerebral Cortex (New York, N.Y. : 1991)
|July 10, 2023
PubMed
Summary
This summary is machine-generated.

This study reveals novel structural and functional connections between the insula and cingulate cortex using 7T MRI. Findings highlight the insular pole as a potential relay hub, enhancing understanding of brain network function.

Keywords:
7TMRIbraindiffusionpainsalience network

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Area of Science:

  • Neuroimaging
  • Systems Neuroscience
  • Brain Connectivity

Background:

  • The insula and cingulate cortex are crucial for affective, cognitive, and interoceptive processing.
  • The anterior insula (aINS) and anterior mid-cingulate cortex (aMCC) are key hubs of the salience network (SN).
  • Previous 3T MRI studies suggested structural and functional connectivity (SC/FC) between various insular and cingulate subregions.

Purpose of the Study:

  • To investigate the structural connectivity (SC) and functional connectivity (FC) between insula and cingulate subregions using ultra-high field 7T MRI.
  • To elucidate the relationship between SC and FC in these regions.
  • To identify potential relay nodes within the insula-cingulate pathways.

Main Methods:

  • Utilized 7T diffusion tensor imaging (DTI) for SC assessment.
  • Employed resting-state functional magnetic resonance imaging (rs-fMRI) for FC assessment.
  • Analyzed connectivity patterns between specific insular and cingulate subregions.

Main Results:

  • DTI identified strong SC between posterior insula (pINS) and posterior mid-cingulate cortex (pMCC).
  • rs-fMRI revealed strong FC between aINS and aMCC, not directly supported by SC, suggesting a mediating structure.
  • The insular pole exhibited the strongest SC to all cingulate subregions, particularly the pMCC, indicating a potential relay function.

Conclusions:

  • The study provides novel insights into insula-cingulate SC and FC using high-field MRI.
  • Findings suggest distinct pathways for SC and FC between anterior insula and cingulate regions.
  • The insular pole's strong connectivity suggests a critical role as a relay node in brain networks.