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Link between fibrosis-specific biomarkers and interstitial fibrosis in hypertrophic cardiomyopathy

Aleksandra Karabinowska-Małocha1,2, Ewa Dziewięcka3, Magdalena Szymańska4

  • 1Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, Kraków, Poland. akarabinowska@gmail.com.

Kardiologia Polska
|July 11, 2023
PubMed

Insights

Galectin-3 levels predict interstitial fibrosis in hypertrophic cardiomyopathy (HCM) patients, as measured by extracellular volume (ECV) via cardiac magnetic resonance. Other fibrosis biomarkers were not useful, but cardiac biomarkers showed a positive correlation with fibrosis.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Medical Imaging

Background:

  • Cardiac fibrosis, particularly interstitial fibrosis, is a significant factor in hypertrophic cardiomyopathy (HCM) with clinical implications.
  • Interstitial fibrosis is less understood compared to replacement fibrosis in HCM.
  • Understanding interstitial fibrosis is crucial for managing HCM progression.

Purpose of the Study:

  • To investigate the association between serum biomarkers and interstitial fibrosis in HCM patients.
  • To assess interstitial fibrosis using extracellular volume (ECV) measured by cardiac magnetic resonance (CMR).
  • To identify potential biomarkers for predicting interstitial fibrosis in HCM.

Main Methods:

  • 50 HCM patients underwent 3T CMR to quantify interstitial fibrosis via ECV.
  • Serum levels of cardiac biomarkers (troponin T, NT-proBNP) and fibrosis biomarkers were measured.
  • Patients were stratified based on median ECV values for comparative analysis.

Main Results:

  • Galectin-3 and body mass index were identified as independent predictors of ECV.
  • Serum galectin-3, troponin T, and NT-proBNP levels significantly correlated with ECV.
  • Patients with higher ECV showed significant differences in NT-proBNP and galectin-3 levels.

Conclusions:

  • Galectin-3 is a valuable independent predictor of interstitial fibrosis in HCM, indicated by elevated ECV.
  • Standard fibrosis-specific biomarkers were not effective in detecting interstitial fibrosis in this HCM cohort.
  • A positive correlation exists between traditional cardiac biomarkers and interstitial fibrosis in HCM patients.
Abstract

Keywords:
ECVgalectin-3hypertrophic cardiomyopathymyocardial fibrosis

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