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lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

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Related Experiment Video

Updated: Jul 23, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

CircRNA: a rising star in leukemia.

Qianan Li¹, Xinxin Ren¹, Ying Wang¹

¹College of Life Sciences, Zhejiang Normal University, Jinhua, China.

|July 11, 2023

Summary

Circular RNAs (circRNAs) are non-coding RNAs implicated in tumor progression. This review details their role in leukemia, including immune modulation, chemoresistance, and potential as diagnostic and prognostic biomarkers.

Keywords:

Biomarker Chemoresistance Immune modulation Leukemia circRNA

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Published on: June 16, 2017

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

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Published on: June 15, 2016

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Last Updated: Jul 23, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Area of Science:

Molecular Biology
Oncology
RNA Biology

Background:

Non-coding RNAs (ncRNAs) lack protein-coding potential.
Circular RNAs (circRNAs) are a novel class of ncRNAs with unique covalent loop structures.
Aberrant circRNA expression is observed in various human cancers, including leukemia.

Conclusions:

CircRNAs are crucial regulators in leukemia development and progression.
CircRNAs offer promising avenues for improving leukemia diagnosis, prognosis, and therapeutic strategies.
Further preclinical research is essential to validate circRNAs as reliable in vivo biomarkers for leukemia.