Related Experiment Video
Updated: Jul 23, 2025
05:48
Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry
Published on: September 5, 2014
9.7K
Temperature-Tuning Desorption Ionization for Ambient Mass Spectrometry
Ningxi Li1, Zhijun Cai1, Zhongyao Zhang1
1State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China.
Analytical Chemistry
|July 11, 2023
Summary
A new temperature-tuning desorption ionization (TTDI) method enables versatile on-site mass spectrometry (MS) analysis. This technique uses a dynamic temperature range for optimal ionization of diverse chemical and biological samples.
Area of Science:
- Analytical Chemistry
- Chemical Engineering
- Biotechnology
Background:
- Mass spectrometry (MS) is increasingly utilized for on-site analysis.
- Advancements in ambient ionization and MS miniaturization have driven this trend.
Purpose of the Study:
- To develop a versatile temperature-tuning desorption ionization (TTDI) method for on-site MS applications.
- To leverage a miniature MS system with TTDI for broad sample analysis.
Main Methods:
- Developed the temperature-tuning desorption ionization (TTDI) method.
- Utilized a miniature mass spectrometer system.
- Employed a dynamic temperature range from 30 to 800 °C for optimal desorption ionization.
Main Results:
- Demonstrated TTDI's versatility for on-site MS analysis.
- Successfully analyzed explosives on surfaces.
- Detected drugs of abuse in biofluids.
- Screened biomarkers in tissues.
Conclusions:
- The TTDI method offers a flexible approach for on-site MS.
- TTDI is effective for analyzing diverse chemical and biological compounds.
- This technology enhances the capabilities of miniature MS systems for field applications.
More Related Videos
Related Concept Videos
01:27Atomic Spectroscopy: Effects of Temperature
370
Atomization, converting samples into gas-phase atoms and ions, is essential for atomic spectroscopy. The flame temperature required for atomization affects the efficiency of the atomic spectroscopic methods by increasing the atomization efficiency and the relative population of the excited and ground states.
At thermal equilibrium, the relative populations of excited and ground state atoms can be estimated using the Maxwell–Boltzmann distribution. For example, an increase in temperature...
At thermal equilibrium, the relative populations of excited and ground state atoms can be estimated using the Maxwell–Boltzmann distribution. For example, an increase in temperature...
370
01:12Electrospray Ionization (ESI) Mass Spectrometry
940
Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
940
01:16Mass Spectrometers
5.7K
This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
5.7K
01:19Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview
808
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
808
01:25Atomic Absorption Spectroscopy: Interference
849
Interference leads to systematic error in atomic absorption (AA) measurements by enhancing or diminishing the analytical signal or the background. These interferences can be grouped into three main categories: spectral interference, chemical interference, and physical interference.
Spectral interference occurs when signals from other elements or molecules overlap with the analyte signal, falsely elevating or masking the analyte's absorbance. This interference can be corrected using Zeeman,...
Spectral interference occurs when signals from other elements or molecules overlap with the analyte signal, falsely elevating or masking the analyte's absorbance. This interference can be corrected using Zeeman,...
849
01:21Atomic Absorption Spectroscopy: Lab
495
For AAS measurements, samples must be introduced as clear solutions, often requiring extensive preliminary treatment to dissolve materials like soils, animal tissues, and minerals. Common methods for sample preparation include treatment with hot mineral acids, wet ashing, combustion in closed containers, high-temperature ashing, or fusion with reagents.
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing...
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing...
495