Gut Immunobiosis and Biomodulators

Area of Science:

• Microbiology
• Gastroenterology
• Nutritional Science

Background:

• The human gastrointestinal tract harbors a complex gut microbiota essential for host health.
• Microbial balance (eubiosis) supports immune and metabolic homeostasis, while imbalance (dysbiosis) is linked to diseases.
• Dietary modulation of the gut microbiome is a key area for health interventions.

Purpose of the Study:

• To explore the role of dietary biomodulators in managing gut microbiota.
• To investigate the potential of prebiotics, probiotics, and postbiotics for stabilizing or restoring eubiosis.
• To examine advancements in infant formula development using these biomodulators.

Main Methods:

• Review of scientific literature on gut microbiota and dietary interventions.
• Analysis of biomodulators such as prebiotics (HMOs, GOS, FOS), probiotics, and postbiotics.
• Evaluation of current approaches in infant formula fortification.

Main Results:

• Gut microbiota plays a critical role in host health through molecular cross-talk.
• Dysbiosis is associated with various diseases, highlighting the need for interventions.
• Dietary strategies can target the gut microbial ecosystem to promote eubiosis.

Conclusions:

• Dietary manipulation using biomodulators is a promising approach to stabilize gut microbiota.
• New infant formulas are being developed with prebiotics, probiotics, and postbiotics to mimic human milk.
• Achieving nutritional and biological equivalence to human milk in formulas is an ongoing goal.