Related Experiment Video
Updated: Jul 23, 2025

Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts
Published on: January 8, 2017
On the role of polyploid giant cells in oncogenesis and tumorigenesis
1, Diedorf, Augsburg, Bavaria, Germany. vladimir.niculescu@yahoo.com.
Abstract:
This correspondence is in response to the commentary by Jinsong Liu ( https://doi.org/10.1007/s12032-023-02038-1 ) to my article "The evolutionary cancer gene network theory versus embryogenic hypotheses" published in Medical Oncology (40:114, 2023). Liu's commentary engages head-on with the evolutionary cancer genome theory and defends his more histopathologically-embryogenically oriented theory of 2020. The dispute revolves, among other things, around the role of polyploid giant MGRS/PGCCs structures in oncogenesis and tumorigenesis.
Related Concept Videos
Abnormal Proliferation
Cancers Originate from Somatic Mutations in a Single Cell
Cancer
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cells Coordinate Growth and Proliferation
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

