Related Experiment Video
Updated: Jul 23, 2025
Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells
Published on: April 25, 2018
The Role of Small Interfering RNAs in Hepatocellular Carcinoma
Feng Chen1, Wang Zhang1, Xinran Gao1
1Department of Biopharmaceutical, Shanghai Ocean University, Shanghai, 201306, China.
Background:
Hepatocellular carcinoma (HCC), a primary liver cancer with high mortality, is the most common malignant tumor in the world. Currently, the effect of routine treatment is poor, especially for this kind of cancer with strong heterogeneity and late detection. In the past decades, the researches of gene therapy for HCC based on small interfering RNA have blossomed everywhere. This is a promising therapeutic strategy, but the application of siRNA is limited by the discovery of effective molecular targets and the delivery system targeting HCC. As the deepening of research, scientists have developed many effective delivery systems and found more new therapeutic targets.
Conclusions:
This paper mainly reviews the research on HCC treatment based on siRNA in recent years, and summarizes and classifies the HCC treatment targets and siRNA delivery systems.
Insights
Small interfering RNA (siRNA) offers a promising gene therapy for hepatocellular carcinoma (HCC), a deadly liver cancer. Research is advancing effective molecular targets and delivery systems for improved HCC treatment outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Gene Therapy
Background:
- Hepatocellular carcinoma (HCC) is a prevalent and highly fatal liver cancer.
- Current treatments for HCC are often ineffective due to tumor heterogeneity and late detection.
- Gene therapy using small interfering RNA (siRNA) presents a promising avenue for HCC treatment.
Purpose of the Study:
- To review recent advancements in siRNA-based treatments for HCC.
- To summarize and categorize identified therapeutic targets for HCC.
- To classify various siRNA delivery systems developed for HCC.
Main Methods:
- Literature review of recent research on siRNA for HCC.
- Analysis and categorization of identified HCC treatment targets.
- Classification of siRNA delivery systems used in HCC therapy.
Main Results:
- Significant progress has been made in identifying effective molecular targets for siRNA therapy in HCC.
- Numerous advanced delivery systems have been developed to enhance siRNA efficacy in targeting HCC.
- The field shows considerable potential for improved therapeutic strategies.
Conclusions:
- siRNA-based gene therapy is a rapidly developing and promising strategy for hepatocellular carcinoma.
- Continued research into novel targets and sophisticated delivery systems is crucial for clinical translation.
- This review provides a comprehensive overview of the current landscape of siRNA research for HCC.
More Related Videos
Related Concept Videos
02:30siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
02:30Small interfering RNAs (siRNA)
02:15Experimental RNAi
01:23RNA Interference
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
01:22MicroRNAs
02:39lncRNA - Long Non-coding RNAs