Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review

Area of Science:

• Dermatology
• Endocrinology
• Pharmacology

Background:

• 5-alpha reductase inhibitors (5ARIs), finasteride and dutasteride, target testosterone to 5α-dihydrotestosterone conversion.
• These 5ARIs are established treatments for benign prostatic hyperplasia and androgenetic alopecia.
• Hyperandrogenism underlies various dermatological conditions, suggesting potential therapeutic roles for 5ARIs.

Purpose of the Study:

• To review the application of 5ARIs in treating dermatological pathologies.
• To evaluate the efficacy and safety profile of 5ARIs in dermatology.
• To inform dermatological practice regarding 5ARI use for hyperandrogenic conditions.

Main Methods:

• Literature review of studies on 5ARI use in dermatology.
• Analysis of efficacy data for conditions including androgenetic alopecia, acne, frontal fibrosing alopecia, and hirsutism.
• Assessment of safety profiles and adverse events associated with 5ARI therapy.

Main Results:

• 5ARIs demonstrate efficacy in treating androgenetic alopecia, acne, frontal fibrosing alopecia, and hirsutism.
• The safety profile of 5ARIs is generally favorable, but potential adverse events require consideration.
• Evidence supports the role of 5ARIs in managing hyperandrogenic dermatoses.

Conclusions:

• 5ARIs are valuable therapeutic agents for specific dermatological conditions driven by hyperandrogenism.
• Clinicians should weigh the benefits of 5ARI treatment against potential adverse events.
• Further research may elucidate expanded applications of 5ARIs in dermatology.