Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The normal c-wave amplitude in rabbits.

N Naoi, S Y Kim, Y Honda

    Documenta Ophthalmologica. Advances in Ophthalmology
    |July 15, 1986
    PubMed
    Summary

    Cyclic variations in rabbit c-waves present challenges for pharmacological studies. Standardizing c-wave amplitudes is difficult due to interindividual variability, but using the contralateral eye as a control is recommended for topical drug administration.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of neostigmine on the pharmacokinetics of intravenous parathion in rats.

    Research communications in molecular pathology and pharmacology·2002
    Same author

    Diagnostic value of serum IGF-I and IGFBP-3 in growth hormone disorders in adults.

    Hormone research·2002
    Same author

    Cross-cultural adaptation and validation of Korean Western Ontario and McMaster Universities (WOMAC) and Lequesne osteoarthritis indices for clinical research.

    Osteoarthritis and cartilage·2002
    Same author

    c-Jun N-terminal kinase is involved in motility of endothelial cell.

    Experimental & molecular medicine·2002
    Same author

    The impact of biomass harvesting on phosphorus uptake by wetland plants.

    Water science and technology : a journal of the International Association on Water Pollution Research·2002
    Same author

    Suppression of hadrons with large transverse momentum in central Au+Au collisions at root square[s(NN)] = 130 GeV.

    Physical review letters·2002

    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Neuroscience

    Background:

    • The electroretinogram (ERG) c-wave is a key component in assessing retinal function.
    • Pigmented rabbits are commonly used animal models in vision research and drug development.
    • Understanding c-wave variability is crucial for reliable pharmacological assessments.

    Purpose of the Study:

    • To identify and address challenges associated with using c-waves in pharmacological experiments in pigmented rabbits.
    • To evaluate methods for standardizing c-wave measurements in this model.
    • To provide recommendations for optimizing experimental design in rabbit ERG studies.

    Main Methods:

    • Recording of electroretinogram (ERG) c-waves in pigmented rabbits under various experimental conditions.
    • Assessment of c-wave amplitude variations in response to intermittent stimuli and over time.
    • Correlation of c-wave amplitude with standing potential during dark adaptation.
    • Comparison of c-wave amplitudes between contralateral eyes.

    Main Results:

    • Cyclic variations of the c-wave were less pronounced in rabbits compared to other species.
    • C-wave amplitudes exhibited variable responses, reaching equilibrium in some rabbits and increasing over time in others.
    • Standardization of c-waves based on standing potential changes during dark adaptation was hindered by interindividual variations.
    • Similar c-wave amplitudes were observed between the right and left eyes.
    • Reduced interindividual variations in c-wave amplitude were noted under dim light conditions.

    Conclusions:

    • The contralateral eye serves as a suitable control for topical drug administration in rabbit eyes due to similar c-wave amplitudes.
    • Dim light conditions can minimize interindividual variability, improving the reliability of c-wave measurements.
    • The findings support the utility of c-waves in chronic systemic drug administration studies in rabbits, provided appropriate controls and conditions are employed.

    Related Experiment Videos