[Immunocytochemical study of monoclonal antibody 83YH2 in stomach cancer]

Using the avidin biotin complex (ABC) immunocytochemical stain, 97 cases of stomach cancer were examined for monoclonal antibody 83YH2. The positive rate was 82.47% (80/97) in stomach cancer with various types of differentiation. Some gastric epithelial cells and intestinal metaplastic cells near the cancer foci also showed weak positivity. But 83YH2 was not detected in normal human tissues. In the same stomach cancer cases, CEA test was also performed. The positive rate and distribution of CEA was almost similar to that of 83YH2, despite the fact that it was verified, by the immunoblock test, that 83YH2 was a different antigen. The results show that 83YH2 is an associated antigen of stomach cancer.