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Related Experiment Video

Updated: Jul 23, 2025

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
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A biocompatible lipid-based bigel for topical applications.

Noèlia Loza-Rodríguez1, Aina Millán-Sánchez2, Olga López2

  • 1Department of Chemical and Surfactant Technology, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), C/Jordi Girona 18-26, 08034 Barcelona, Spain; Bicosome S.L. C/Jordi Girona 18-26, 08034 Barcelona, Spain.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|July 11, 2023
PubMed
Summary

A novel bigel, combining a colloidal lipid hydrogel and an oleogel, effectively delivers both hydrophilic and lipophilic substances. This biocompatible topical formulation enhances skin penetration, showing promise for medical and dermatological drug delivery.

Keywords:
BigelColloidal lipid hydrogelHydrogelOleogelSkin permeationTopical application

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Pharmaceutical Sciences

Background:

  • Biocompatible delivery systems are crucial for topical and medical applications.
  • Developing effective topical carriers that enhance drug penetration is an ongoing challenge.

Purpose of the Study:

  • To develop and characterize a new bigel formulation for topical drug delivery.
  • To evaluate the potential of this bigel as a carrier for both hydrophilic and lipophilic drugs through the skin in vitro.

Main Methods:

  • A bigel composed of colloidal lipid hydrogel and olive oil/beeswax oleogel was formulated.
  • In vitro skin penetration was assessed using fluorescence microscopy with hydrophilic (sodium fluorescein) and lipophilic (Nile red) probes.
  • Structural characterization employed Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR), Differential Scanning Calorimetry (DSC), and X-ray scattering (SAXS/WAXS).

Main Results:

  • Fluorescence microscopy confirmed a two-phase structure with the hydrogel incorporated into the oleogel matrix.
  • ATR-FTIR, DSC, SAXS, and WAXS provided insights into the bigel's composition, thermal properties, and lamellar structure related to beeswax crystals.
  • The bigel demonstrated enhanced penetration of both hydrophilic and lipophilic probes into deeper skin layers.

Conclusions:

  • The developed bigel exhibits a stable, structured composition suitable for topical applications.
  • This bigel formulation shows significant potential as an effective carrier for enhancing the transdermal delivery of diverse drug types.
  • The findings support the bigel's utility in advanced medical and dermatological treatments.