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Related Experiment Video

Updated: Jul 23, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Refractory type I cryoglobulinaemia requiring serial amputations.

Adam Kelly1, Nicholas Collar2, Lindsay Hammons2

  • 1Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA adkelly@mcw.edu.

BMJ Case Reports
|July 11, 2023
PubMed
Summary

Type I cryoglobulinaemia (TIC) caused severe, refractory necrosis in a middle-aged man, leading to amputations. This rare case highlights diagnostic challenges and aggressive disease management needs.

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Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Hematology

Background:

  • Type I cryoglobulinaemia (TIC) is a rare condition characterized by cryoprecipitable immunoglobulins causing vaso-occlusion.
  • Patients may present with diverse symptoms, including critical limb ischemia, posing diagnostic challenges.
Keywords:
Haematology (incl blood transfusion)Orthopaedic and trauma surgeryVasculitis

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