Related Experiment Video

Updated: Jul 23, 2025

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

3.5K

Intraprocedural, Intra-Arterial CT Foot Perfusion Examination for Assessment of Endovascular Therapy in Patients With

Thijs Urlings1, Apoorva Gogna2, Mark C Burgmans3

  • 1Haaglanden Medical Center, The Hague, The Netherlands.

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
|July 12, 2023
PubMed

Insights

Intra-arterial computed tomography (CT) foot perfusion is a feasible technique for assessing endovascular treatment in critical limb ischemia patients. This method uses low contrast doses and can be performed during procedures, improving patient care.

Area of Science:

  • Medical Imaging
  • Vascular Surgery
  • Radiology

Background:

  • Current computed tomography (CT) foot perfusion techniques for critical limb ischemia (CLI) require high contrast doses and are incompatible with endovascular procedures.
  • Intra-arterial contrast injection during endovascular treatment in a hybrid angiography CT suite offers a potential solution.

Purpose of the Study:

  • To evaluate the feasibility of intra-arterial CT foot perfusion using a hybrid CT angiosystem during endovascular treatment for CLI.

Main Methods:

  • A prospective pilot study involving 12 patients with CLI undergoing endovascular treatment.
  • Intraprocedural, intra-arterial CT perfusion of the foot was performed before and after treatment.
  • Measurements included time to peak (TTP) and arterial blood flow, analyzed with a paired t-test.

Main Results:

  • All 24 CT perfusion maps were successfully calculated with a low contrast volume (4.8 ml).
  • Mean TTP significantly decreased post-treatment (8.4s) compared to pre-treatment (12.8s) (p=.001).
  • A trend towards increased blood flow was observed post-treatment (514 ml/min/100 ml vs 340 ml/min/100 ml, p=.104). Mean effective radiation dose was 0.145 mSv per scan.

Conclusions:

  • Intra-arterial CT foot perfusion with low contrast dose in a hybrid suite is a feasible technique for endovascular treatment of CLI.
  • This technique allows for immediate assessment of treatment results.
  • Further research is needed to define endpoints and its role in limb salvage prognostication.
Abstract

Keywords:
3D perfusion mapCT perfusioncontrast injectionhybrid angiography CTlower limb ischemia

More Related Videos

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

1.5K
Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels04:35

Sample Preparation for Computed Tomography-based Three-dimensional Visualization of Murine Hind-limb Vessels

Published on: October 7, 2021

2.4K

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
11
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
17
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
12
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
383
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
69
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
32