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Significant correlation between glucose metabolism status and acute radiation enteritis resulting from concurrent
Yuan Gao1,2, Lingjun Meng3
1Tongji University School of Medicine Shanghai 200092, China.
Objective:
To explore the relationship between glucose metabolism and acute radiation enteritis from chemoradiotherapy for rectal cancer.
Methods:
In this retrospective study, the clinical data of 75 rectal cancer patients who received concurrent chemoradiotherapy in Binzhou Second People's Hospital from February 2019 to February 2022 were collected and analyzed. According to the Radiation Therapy Oncology Group (RTOG)/European Organization for Research on Treatment of Cancer (EORTC) radiation response grading criteria, the patients were classified into four groups with different glucose metabolism statuses: NGR (normal glucose regulation) group, IFG (impaired fasting glucose) group, IGT (impaired glucose tolerance) group, and DM (diabetes mellitus) group. Two-factor logistic regression was used to analyze whether IFG, IGT, or DM were risk factors for acute radiation enteritis.
Results:
(1) The fasting plasma glucose (FPG, F=20.550, P < 0.001), 2-hour post-meal blood glucose (2hPG, F=14.920, P < 0.001), triglycerides (TG, F=3.355, P=0.024), high-density lipoprotein cholesterol (HDL-C) (F=4.109, P=0.010), low-density lipoprotein cholesterol (LDL-C, F=4.545, P=0.006), and systolic blood pressure (SBP, F=5.398, P=0.002) differed greatly among the NGR group, IFG group, IGT group, and DM group, all P < 0.05. (2) The incidence of acute radiation enteritis was 34.67% in the 75 patients, and in DM patients it was higher than in the NGR, IFG, or IGT patients (χ2=14.702, P=0.002). (3) There were significant differences in BMI (F=3.594, P=0.044) and DBP (F=3.954, P=0.033) among the asymptomatic group, mild group, and severe group (P < 0.05). (4) Body mass index (BMI) was positively correlated with acute radiation enteritis in IFG, IGT, and DM patients (OR=1.361, P=0.020). (5) DM was positively correlated with acute radiation enteritis (OR=6.167, P=0.039).
Conclusions:
DM was significantly correlated with acute radiation enteritis induced by concurrent chemoradiotherapy for rectal cancer, while IFG and IGT were not.
