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Correlation Between Intracranial Calcification and Extracranial Stenosis of the Internal Carotid Artery

Julia R Jahansooz1,2, Andrew Ko1,2, Ryoko Hiroi1,2

  • 1Neurology, John A. Burns School of Medicine, Honolulu, USA.

Cureus
|July 12, 2023
PubMed

Insights

Intracranial artery calcification correlates with carotid artery stenosis. Older individuals with intracranial calcification had narrower arteries and greater stenosis, suggesting a link between neck and brain vessel disease.

Area of Science:

  • Radiology
  • Vascular Medicine
  • Neurology

Background:

  • Intracranial artery calcification is a prevalent marker of vascular atherosclerosis.
  • Both intracranial calcification and carotid artery atherosclerosis are linked to ischemic stroke.
  • The relationship between extracranial carotid stenosis and intracranial calcification remains understudied.

Purpose of the Study:

  • To investigate the association between carotid sinus narrowing and intracranial calcification in the cavernous carotid artery.
  • To examine this relationship in a general population without pre-existing cerebral disease.

Main Methods:

  • Retrospective study of 179 subjects (≥18 years) from the Hawaii Diagnostic Radiology database.
  • Extracranial internal carotid artery stenosis assessed using diameter, NASCET, and CCA methods.
  • Intracranial calcification quantified using the modified Woodcock method.

Main Results:

  • A significant positive correlation was found between intracranial calcification and extracranial carotid stenosis across all measurement methods.
  • Individuals with intracranial calcification were older, had smaller internal carotid artery diameters, and greater percent stenosis (p<0.001).

Conclusions:

  • The study demonstrates a correlation between intracranial calcification and extracranial carotid stenosis.
  • Findings suggest a potential link between calcification in cerebral vasculature and extracranial carotid artery disease.
  • Highlights the importance of considering extracranial factors in intracranial calcification studies.

Keywords:
carotid artery diseaseextracranial stenosisinternal carotid arteryintracranial calcificationischemic strokevascular calcification

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