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Updated: Jul 23, 2025
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Detecting Glycogen in Peripheral Blood Mononuclear Cells with Periodic Acid Schiff Staining
Published on: December 23, 2014
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Glycogen-binding protein STBD1: Molecule and role in pathophysiology
Qiannan Tang1, Meiqing Liu2, Hong Zhao3
1Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, Hengyang Medical School, University of South China, Hengyang, China.
Journal of Cellular Physiology
|July 12, 2023
Summary
Starch-binding domain-containing protein 1 (STBD1) is crucial for cellular energy metabolism and glycogen storage. Its dysregulation is linked to diseases like cancer, highlighting its potential as a therapeutic target.
Area of Science:
- Biochemistry
- Molecular Biology
- Cellular Metabolism
Background:
- Starch-binding domain-containing protein 1 (STBD1) is a glycogen-binding protein identified in skeletal muscle.
- It plays a key role in cellular energy metabolism, influencing processes like glycophagy and glycogen accumulation.
Purpose of the Study:
- To review the current understanding of STBD1, including its structure, localization, distribution, and functions.
- To examine the roles and molecular mechanisms of STBD1 in various diseases.
- To discuss the future potential of STBD1 as a therapeutic target.
Main Methods:
- Literature review of existing research on STBD1.
- Analysis of STBD1's involvement in physiological processes.
- Investigation of STBD1's role in disease pathology.
Main Results:
- STBD1 is involved in glycophagy, glycogen accumulation, and lipid droplet formation.
- STBD1 dysregulation is associated with cardiovascular disease, metabolic disease, and cancer.
- Mutations in STBD1 can promote tumorigenesis.
Conclusions:
- STBD1 is significant in energy metabolism and disease pathology.
- Understanding STBD1 is vital for developing therapeutic strategies for glycogen-related diseases.
- STBD1 presents potential as a therapeutic target for metabolic and oncological conditions.
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