Multicomponent-Loaded Vesosomal Drug Carrier for Controlled and Sustained Compound Release

Area of Science:

• Biotechnology
• Materials Science
• Nanotechnology

Background:

• Liposomes are widely used in drug delivery, but challenges exist in co-delivering multiple drugs and controlling their release rates.
• Existing systems often lack the precision needed for complex therapeutic regimens requiring differential release profiles.

Purpose of the Study:

• To develop a novel vesosomal carrier system for controlled and sustained release of multiple components.
• To engineer a dual-liposome structure capable of differential drug release kinetics.

Main Methods:

• Co-encapsulation of inner liposomes with varying lipid compositions and a photosensitizer within an outer liposome.
• Induction of reactive oxygen species (ROS) to trigger content release.
• In vitro release assays and in vivo validation using *Caenorhabditis elegans*.

Main Results:

• Demonstrated differential release kinetics from inner liposomes based on lipid peroxidation and structural deformation.
• Observed immediate release from ROS-vulnerable liposomes followed by sustained release from ROS-nonvulnerable liposomes.
• Validated the ROS-triggered release mechanism in a whole organism model.

Conclusions:

• The developed dual-liposome system offers a promising platform for precise control over the release of multiple therapeutic agents.
• This approach enables tunable drug release profiles, enhancing the potential for complex drug delivery strategies.
• The findings pave the way for advanced nanomedicine formulations with improved therapeutic outcomes.