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Transition Metal Complexes as Antimalarial Agents: A Review.
Apurba Mandal1, Rajesh Kushwaha1, Arif Ali Mandal1
1Department of Chemistry, Indian Institute of Technology (BHU), 221005, Varanasi, India.
Chemmedchem
|July 12, 2023
Summary
Developing novel antimalarial drugs is crucial due to increasing resistance. Transition metal complexes of existing antimalarials show promise for enhanced efficacy and overcoming resistance.
Area of Science:
- Medicinal Chemistry
- Inorganic Chemistry
- Parasitology
Background:
- Drug resistance to current antimalarials like chloroquine and artemisinin is a significant challenge in malaria treatment.
- Novel therapeutic strategies are urgently needed to combat malaria effectively.
- Transition metal complexes offer a promising avenue for developing new antimalarial agents.
Purpose of the Study:
- To review recent advancements in transition metal complexes as novel antimalarial agents.
- To explore the potential of metal complexation in overcoming existing drug resistance mechanisms.
- To analyze the efficacy of 3d, 4d, and 5d metal-based antimalarial complexes.
Main Methods:
- Literature review of research on transition metal complexes with antimalarial pharmacophores.
- Categorization of complexes based on the transition metal series (3d, 4d, 5d).
- Comparative analysis of antimalarial activity of metal complexes versus parent drugs and control complexes.
Main Results:
- Metal complexation of known antimalarial drugs can enhance their activity and overcome resistance.
- Complexes across different transition metal series (3d, 4d, 5d) exhibit varying antimalarial profiles.
- Evidence suggests metal complexes can offer novel mechanisms of action against malaria parasites.
Conclusions:
- Transition metal complexes represent a viable strategy for developing next-generation antimalarial drugs.
- Further research and development are needed to translate these promising metal-based complexes into clinical applications.
- Addressing potential challenges is key to the successful clinical translation of these novel therapeutics.
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