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Salivary biomarkers as potential diagnostic tool for temporomandibular disorders: A comprehensive review
Yasmina Aoun1, Rita Ejbeh1, Abboud Youssef2
1Resident at the Department of Orthodontics and Dentofacial Orthopedics, Faculty of Dental Medicine, Saint Joseph University of Beirut, Beirut, Lebanon.
Objective:
To review the current scientific literature concerning the implication of biomarkers collected from saliva in the diagnosis of temporomandibular disorders (TMD).
Methods:
A comprehensive literature search was conducted on PubMed, Google Scholar, Embase, MEDLINE and Web of Science to gather articles published between 2012 and 2021. Based on the eligibility criteria, articles were reviewed in full and precise data was extracted.
Results:
Nine clinical studies were selected. Participants with TMD were all diagnosed according to the Diagnostic Criteria for Temporomandibular Disorders. Specific biomarkers were examined from saliva samples. Results related to TMD showed a significant range of variability.
Conclusion:
Specific salivary biomarkers have been investigated, but current efforts are aiming to search for more possible biomarkers from saliva samples as a safe procedure. Future research needs to consider the sensitivity and specificity of these biomarkers as diagnostic tools for TMD.
