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Esophageal Lichen Planus: A Descriptive Multicenter Report
Elizabeth S Aby1, Jason D Eckmann1, Jad Abimansour2
1Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition.
Journal of Clinical Gastroenterology
|July 12, 2023
Summary
Esophageal lichen planus (ELP) is a rare condition often missed. This study highlights its characteristics, frequent strictures, and varied treatments, emphasizing the need for better diagnostic suspicion and further research into effective therapies.
Area of Science:
- Gastroenterology
- Dermatology
- Immunology
Background:
- Esophageal lichen planus (ELP) is a rare disorder frequently misdiagnosed.
- Limited data exist on this patient population, primarily from small, single-center studies.
Purpose of the Study:
- To characterize the clinical features, treatment strategies, and outcomes of patients with ELP.
- To identify common endoscopic findings and management approaches for ELP.
Main Methods:
- A multicenter, retrospective descriptive study was conducted.
- Data from 7 US centers over a 5-year period (2015-2020) were analyzed.
- Included 78 adult patients diagnosed with ELP.
Main Results:
- The study included 78 patients (65 years old, 86% female, 90% Caucasian).
- Over half had extraesophageal manifestations. Esophageal strictures (54%) and abnormal mucosa (50%) were common endoscopic findings.
- Topical steroids and proton pump inhibitors were primary treatments; steroids showed better endoscopic response. Nearly half required treatment changes.
Conclusions:
- A high index of suspicion and biopsy are crucial for diagnosing ELP, especially with extraesophageal involvement.
- Effective therapies are limited and vary; prospective studies are needed to determine optimal treatment regimens.
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