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The Real Relevance of Nonacid Reflux in Pediatric Patients
1Aerodigestive Center, Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Hepatology & Nutrition, Boston Children's Hospital, Boston, MA.
Insights
Nonacid gastroesophageal reflux (GER) significantly impacts children, presenting diverse symptoms. This review examines nonacid GER
Area of Science:
- Pediatric Gastroenterology
- Gastrointestinal Physiology
Background:
- Gastroesophageal reflux (GER) is a common pediatric complaint.
- Traditional GER management focuses on acid suppression.
- Nonacid GER is increasingly recognized in pediatric populations.
Conclusions:
- Nonacid GER is a significant factor in pediatric reflux symptomatology.
- Further research is needed to fully understand and manage nonacid GER.
- Considering nonacid reflux is crucial for comprehensive pediatric GER care.
Abstract:
Gastroesophageal reflux (GER) is one of the most common presenting complaints to pediatric gastroenterologists, and a wide variety of symptoms in children are potentially attributable to typical or atypical GER. While reflux diagnosis and treatment paradigms classically have focused on targeting acid, there is a growing recognition of the prevalence and significance of nonacid GER in both children and adults. This review explores the role of nonacid reflux in pediatric patients, including definitions, associations with symptoms, pathophysiologic mechanisms, and treatment implications.
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