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Updated: Jul 23, 2025
00:09
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
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Prenatal Genetic Screening in Twin Pregnancy
Lauren Buckley1, Maeve Hopkins1, Jeffrey A Kuller2
1Obstetrics & Gynecology Institute, Cleveland Clinic, Cleveland, Ohio.
Clinical Obstetrics and Gynecology
|July 12, 2023
Summary
Screening for aneuploidy in twin pregnancies requires careful consideration. This review discusses available screening options, their benefits, and limitations for expectant parents.
Area of Science:
- Maternal-Fetal Medicine
- Prenatal Diagnostics
- Genetics
Background:
- Twin pregnancies have unique implications for prenatal screening.
- Comprehensive pre-test counseling is essential for all twin pregnancies.
- Understanding screening options is crucial for informed decision-making.
Purpose of the Study:
- To review current aneuploidy screening methods for twin pregnancies.
- To outline the benefits and limitations of each screening option.
- To guide healthcare providers in counseling patients with twin pregnancies.
Main Methods:
- Literature review of existing studies on aneuploidy screening in twins.
- Analysis of diagnostic accuracy and clinical utility of various screening modalities.
- Synthesis of information on benefits, risks, and limitations.
Main Results:
- Aneuploidy screening in twins presents challenges compared to singleton pregnancies.
- Non-invasive prenatal testing (NIPT) shows promise but requires careful interpretation in twins.
- Traditional methods like ultrasound and biochemical screening remain relevant.
Conclusions:
- Tailored aneuploidy screening strategies are necessary for twin gestations.
- Informed patient choice, supported by thorough counseling, is paramount.
- Further research is needed to optimize screening protocols for twin pregnancies.
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