Bicyclic thiophenic derivatives as platelet aggregation inhibitors

The antiplatelet activity of twenty new thiophenic derivatives, grouped in three series, was studied according to the in vitro Born method. The DI50 for the three inducers of platelet aggregation ADP, adrenaline and collagen were calculated. The strong antiplatelet activity found in some of the compounds studied, which is even superior to that of the four classic antiplatelet drugs used is worth mentioning. The structure-activity relationships is discussed.