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Updated: Aug 15, 2026

Polysome Profiling in Leishmania, Human Cells and Mouse Testis
Published on: April 8, 2018
Translational regulation of ornithine decarboxylase by polyamines
Abstract:
The activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, is dramatically increased in proliferating cells. In addition to transcriptional regulation of ODC, the present study shows that the enzyme is regulated at the translational level by putrescine and spermidine. ODC synthesis is inhibited by an increase and stimulated by a decrease in their cellular content. Spermidine is a more potent negative regulator than is putrescine. The effects of polyamines on ODC synthesis were not attributable to changes in the cellular content of ODC mRNA, thus demonstrating regulation at the translational level.
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