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Related Experiment Video

Updated: Jul 23, 2025

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
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LungElast-an open-source, flexible, low-cost, microprocessor-controlled mouse lung elastometer.

Jesse D Roberts1,2

  • 1Cardiovascular Research Center of the General Medical Services and the Departments of Anesthesia, Critical Care and Pain Medicine, Pediatrics, and Medicine, Massachusetts General Hospital - East, 149 13th St, Boston, MA, USA. roberts@cvrc.mgh.harvard.edu.

Scientific Reports
|July 12, 2023
PubMed
Summary
This summary is machine-generated.

LungElast is an affordable, open-source device for measuring mouse lung mechanics. This instrument precisely determines lung elasticity and volumes, aiding pulmonary disease research and education.

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Area of Science:

  • Physiology
  • Biomedical Engineering
  • Pulmonary Medicine

Background:

  • Mouse lung mechanics research is vital for understanding pulmonary diseases.
  • Current custom systems are costly and difficult to regulate.
  • Investigating lung function requires specialized, often expensive, equipment.

Purpose of the Study:

  • To introduce LungElast, an open-source, cost-effective instrument for measuring mouse lung elasticity and volumes.
  • To provide a self-contained, user-friendly alternative to existing complex systems.
  • To enable research and educational applications, even with immature mice.

Main Methods:

  • Utilizes a microprocessor-controlled stepper motor and time-of-flight LIDAR for precise volume control.
  • Employs compact sensor-on-chip technology for digital airway pressure measurement.
  • Assembled from 3D printed parts and readily available components for affordability and accessibility.

Main Results:

  • Demonstrates accurate and precise measurement of lung elasticity and volumes.
  • Validated using lung models and mouse pups, showing reliable performance.
  • The modular software facilitates device testing, calibration, and operation.

Conclusions:

  • LungElast offers a low-cost, accessible solution for studying mouse lung mechanics.
  • The instrument is suitable for both research and educational settings.
  • Facilitates advancements in understanding pulmonary disease mechanisms.