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Related Experiment Video

Updated: Jun 23, 2026

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

Published on: May 15, 2014

Engineering prostate cancer in vitro: what does it take?

Adriana Buskin¹, Emma Scott¹, Ryan Nelson¹

¹Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Paul O'Gorman Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

|July 12, 2023

Summary

This summary is machine-generated.

Prostate cancer (PCa) heterogeneity challenges treatment. Advanced 3D organoid models show promise for personalized therapies, but require engineering improvements to better mimic the tumor microenvironment and metastasis.

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Last Updated: Jun 23, 2026

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Published on: March 6, 2018

Area of Science:

Oncology
Biotechnology
Tissue Engineering

Background:

Prostate cancer (PCa) exhibits significant molecular, cellular, and clinical heterogeneity, complicating treatment and leading to therapeutic failure.
Current preclinical models struggle to fully recapitulate this diversity and resistant phenotypes, hindering the development of effective personalized PCa therapies.
Three-dimensional (3D) organoid models have emerged as powerful tools, reflecting heterogeneity and enabling genomic/environmental manipulation for applications in disease modeling and drug screening.

Purpose of the Study:

To review current in vitro 3D prostate cancer models, with a focus on organoids.
To discuss engineering approaches for developing more physiologically relevant PCa organoid models.
To enhance the translational relevance of organoid models for precision medicine in prostate cancer.

Main Methods:

Review of current literature on 3D prostate cancer models, particularly organoids.
Analysis of technological advances in tissue engineering for cancer model development.
Discussion of strategies to improve the recapitulation of the tumor microenvironment and epigenome in organoid models.

Main Results:

Organoid technology offers significant advantages in modeling PCa heterogeneity and drug response.
Existing organoid models have limitations in fully replicating the tumor microenvironment, metastasis, and epigenome.
Engineering approaches hold potential for creating advanced 3D PCa models with improved in vivo functionality.

Conclusions:

Further engineering of 3D organoid models is crucial for overcoming current limitations.
Enhanced PCa organoid models will improve preclinical research and accelerate the development of precision medicine.
Optimizing organoid models is key to realizing their full potential in transforming prostate cancer treatment.