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Related Concept Videos

Chirality in Nature02:30

Chirality in Nature

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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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Prochirality02:05

Prochirality

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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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Chirality02:25

Chirality

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Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
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Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

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Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
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Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

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Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
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Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

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Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
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Updated: Jul 23, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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Chiral Supramolecular Assemblies: Controllable Construction and Biological Activity.

Sijia He1, Zichao Jiang1, Xiaoqiu Dou1

  • 1State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.

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|July 12, 2023
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Chiral supramolecular assemblies mimic biological helices like DNA and proteins. Understanding their structure is key for developing new chiral biomedical materials for tissue regeneration and disease treatment.

Keywords:
biological activitybiomedical materialschiralityself-assemblysupramolecular chemistry

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Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
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Area of Science:

  • Biomaterials Science
  • Supramolecular Chemistry
  • Nanotechnology

Background:

  • Chiral supramolecular assemblies with helical structures are vital in biological systems, influencing physiological activities.
  • Alterations in chiral structures can lead to abnormal physiological functions.
  • Artificial supramolecular assemblies with controlled helical orientation are needed to study natural helix construction and function.

Purpose of the Study:

  • To review recent advancements in chiral supramolecular assembly.
  • To discuss the precise construction and regulation of chiral nanostructures with tunable chirality.
  • To explore chiral structure-dependent biological activities and their therapeutic implications.

Main Methods:

  • Review of recent literature on chiral supramolecular assembly.
  • Discussion of methods for constructing and regulating chiral nanostructures.
  • Analysis of structure-activity relationships in biological contexts.

Main Results:

  • Recent progress in fabricating artificial chiral supramolecular assemblies with controllable helical structures.
  • Demonstration of tunable chirality in assembled nanostructures.
  • Evidence of chiral structure-dependent biological activities, including cell proliferation, differentiation, antibacterial effects, and tissue regeneration.

Conclusions:

  • Understanding chiral supramolecular assemblies is crucial for comprehending physiological processes.
  • This field is vital for developing advanced chiral biomedical materials.
  • Applications include tissue engineering regeneration and stem cell transplantation therapy.