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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
Recent advances in BCRP-induced breast cancer resistance treatment with marine-based natural products
Jovita Kanoujia1, Anjali Das2, Neha Raina3
1Amity Institute of Pharmacy, Amity University Madhya Pradesh (AUMP), Gwalior, India.
Abstract:
Breast cancer is the prominent cause of cancer-related death in women globally in terms of incidence and mortality. Despite, recent advances in the management of breast cancer, there are still a lot of cases of resistance to medicines, which is currently one of the biggest problems faced by researchers across the globe. Out of several mechanisms, breast cancer resistance protein (BCRP) arbitrated drug resistance is a major concern. Hormonal, cytotoxic and immunotherapeutic drugs are used in the systemic therapy of breast cancer. It is vital to choose drugs based on the clinical and molecular attributes of the tumor to provide better treatment with greater efficacy and minimal harm. Given the aforementioned necessity, the use of marine flora in treating breast cancer cannot be neglected. The scientists also stressed the value of marine-derived goods in avoiding breast cancer resistance. Future research into the identification of anticancer drugs will heavily draw upon the marine environment's ample supply of marine-derived natural products (MNPs), which have a wide range of biological functions. Cell cycle arrest, induction of apoptosis and anti-angiogenic, anti-proliferative and anti-metastasis actions are all part of their processes. The overview of breast cancer, the mechanisms underlying its resistance, recent clinical trials based on marine-derived products in breast cancer and the use of marine products in the treatment of breast cancer are highlighted in this paper. Moreover, the authors also emphasised the importance of marine-derived products in preventing breast cancer resistance.
Insights
Marine-derived natural products show promise in overcoming breast cancer drug resistance, offering new therapeutic avenues. Research highlights their potential to combat cancer progression and improve treatment efficacy.
Area of Science:
- Oncology
- Marine Biotechnology
- Pharmacology
Background:
- Breast cancer remains a leading cause of cancer-related mortality in women worldwide.
- Drug resistance, particularly mediated by breast cancer resistance protein (BCRP), poses a significant challenge in breast cancer treatment.
- Effective treatment requires personalized drug selection based on tumor characteristics.
Purpose of the Study:
- To review the role of marine-derived natural products (MNPs) in addressing breast cancer.
- To explore the potential of MNPs in overcoming drug resistance mechanisms.
- To highlight recent clinical trials and therapeutic applications of marine products in breast cancer treatment.
Main Methods:
- Review of existing literature on breast cancer, drug resistance mechanisms, and marine-derived products.
- Analysis of the biological functions and anticancer properties of MNPs.
- Examination of clinical trials involving marine products for breast cancer therapy.
Main Results:
- Marine flora and derived products demonstrate significant potential in preventing and treating breast cancer.
- MNPs exhibit diverse anticancer activities, including cell cycle arrest, apoptosis induction, and anti-angiogenic, anti-proliferative, and anti-metastasis effects.
- Marine-derived compounds are valuable resources for developing novel anticancer drugs and overcoming resistance.
Conclusions:
- Marine-derived natural products are crucial for developing new strategies against breast cancer, especially in overcoming drug resistance.
- Further research into MNPs is essential for identifying effective anticancer agents and improving patient outcomes.
- The marine environment offers a rich source of compounds with broad biological functions for cancer therapy.
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