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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Drug Elimination by Renal Route: Tubular Secretion01:15

Drug Elimination by Renal Route: Tubular Secretion

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Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...
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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

34
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Related Experiment Video

Updated: Jul 23, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Targeting the Complement Pathway in Kidney Transplantation.

Dela Golshayan1, Nora Schwotzer2, Fadi Fakhouri2

  • 1Transplantation Center , Department of Medicine , Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland.

Journal of the American Society of Nephrology : JASN
|July 13, 2023
PubMed
Summary
This summary is machine-generated.

The complement system is crucial in kidney transplantation (KTx) but can cause injury. New complement blockers offer hope for better outcomes by targeting pathways involved in rejection and recurrence.

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Area of Science:

  • Immunology
  • Transplantation Medicine
  • Nephrology

Background:

  • The complement system is vital for pathogen clearance but implicated in allograft injury after kidney transplantation (KTx).
  • Growing interest exists in biomarkers for complement activation to guide KTx therapies.
  • Complement-driven diseases like atypical hemolytic uremic syndrome and C3 glomerulopathy show potential for complement-targeted treatments.

Purpose of the Study:

  • To review the role of the complement system in kidney allograft injury.
  • To discuss the potential of novel complement inhibitors in KTx.
  • To explore strategies for optimizing complement blockade in different KTx scenarios.

Main Methods:

  • Review of current literature on complement system activation in kidney transplantation.
  • Analysis of clinical trial outcomes for complement inhibitors.
  • Discussion of emerging technologies like ex vivo organ perfusion for drug delivery.

Main Results:

  • C5 blockade is effective for atypical hemolytic uremic syndrome but less so for highly sensitized KTx patients.
  • Complement activation contributes to ischemia reperfusion injury and antibody-mediated rejection (ABMR).
  • New complement blockers show promise for mitigating ischemia reperfusion, ABMR, and recurrence.

Conclusions:

  • Optimizing the timing, strategy, and type of complement inhibition is necessary for KTx.
  • Ex vivo organ perfusion presents new opportunities for targeted complement therapy.
  • Emerging complement blockers may significantly improve KTx outcomes by addressing key injury pathways.