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Current Progress in Stem Cell Therapy for Male Infertility
Rajendra Falah Adriansyah1, Ria Margiana2,3,4,5,6,7, Supardi Supardi8,9
1Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Stem Cell Reviews and Reports
|July 13, 2023
Summary
Male infertility affects many couples, and current treatments like assisted reproductive technology (ART) are insufficient. Stem cell therapies, including spermatogonial stem cells (SSCs) and induced pluripotent stem cells (iPSCs), show promise for treating male infertility.
Area of Science:
- Reproductive Medicine
- Stem Cell Biology
- Andrology
Background:
- Infertility is a global issue, with male factors contributing to approximately 50% of cases.
- Existing treatments, such as assisted reproductive technology (ART), have limitations in effectively addressing male infertility.
- Stem cells offer potential due to their self-renewal and differentiation capabilities for reproductive disorders.
Purpose of the Study:
- To identify causes and influencing factors of male fertility.
- To review recent research on stem cell applications in treating male infertility.
- To evaluate the efficacy of various stem cell types in male infertility treatment.
Main Methods:
- Literature review of recent studies on male infertility.
- Analysis of research investigating stem cell therapies.
- Identification of stem cell types, including spermatogonial stem cells (SSCs), embryonic stem cells (ESCs), very small embryonic-like stem cells (VSELs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs).
Main Results:
- Stem cells demonstrate potential for generating male and female gametes.
- Various stem cell types are being investigated for their therapeutic efficiency in different forms of male infertility.
- Research highlights the promise of stem cells as a novel approach to male infertility treatment.
Conclusions:
- Stem cell therapy represents a promising avenue for addressing the limitations of current male infertility treatments.
- Further research into spermatogonial stem cells (SSCs), induced pluripotent stem cells (iPSCs), and other stem cell types is crucial.
- Stem cells hold significant potential for restoring fertility in males affected by various conditions.
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