Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.7K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.7K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

3.4K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
3.4K
Mitochondrial Precursor Proteins01:39

Mitochondrial Precursor Proteins

2.6K
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial...
2.6K
Mitochondrial Membranes01:45

Mitochondrial Membranes

11.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
11.6K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

14.5K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
14.5K
Mitochondria01:37

Mitochondria

13.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing a Shariah-compliant medical services framework in Malaysia: an expert system approach using fuzzy Delphi method and interpretive structural modelling.

BMJ open·2025
Same author

Applying the Concepts of Benefit and Harm in Malaysian Bioethical Discourse: Analysis of Malaysian Fatwa.

Journal of bioethical inquiry·2024
Same author

Determinants of consumer adoption of halal cosmetics: A systematic literature review.

Journal of cosmetic dermatology·2023
Same author

Three-Dimensional (3D) Printing of Organs according to the Perspective of Islamic Law.

Asian bioethics review·2023
Same author

Sunni Islamic perspectives on lab-grown sperm and eggs derived from stem cells - in vitro gametogenesis (IVG).

The New bioethics : a multidisciplinary journal of biotechnology and the body·2022
Same author

The Lesser of Two Evils: Application of Maslahah-Mafsadah Criteria in Islamic Ethical-Legal Assessment of Genetically Modified Mosquitoes in Malaysia.

Journal of bioethical inquiry·2022
Same journal

Reconciling Subsistence Emissions and Prevention in Environmentally Sustainable Healthcare.

Journal of bioethical inquiry·2026
Same journal

Why the Social Gradient in Health-Related Behaviour is Unjust : An Unconditionalist Perspective.

Journal of bioethical inquiry·2026
Same journal

Mapping the Representation of Race and Other Health Disparities in U.S. Orthopaedic Journals : A Scoping Review.

Journal of bioethical inquiry·2026
Same journal

Safeguarding Physical and Mental Health Rights in African Conflict Regions: Ethical Responsibilities, Barriers, and Collaborative Efforts.

Journal of bioethical inquiry·2026
Same journal

Ibsen's An Enemy of the People and the Ethics of Public Health Disclosure.

Journal of bioethical inquiry·2026
Same journal

Is Unconsciousness the Intention? Physicians' Perspectives on Palliative Sedation Outside Specialized Palliative Care: A Qualitative Study.

Journal of bioethical inquiry·2026
See all related articles

Related Experiment Video

Updated: Jul 23, 2025

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
06:05

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model

Published on: March 9, 2022

3.8K

Mitochondrial Replacement Therapy: An Islamic Perspective.

Abdul Halim Ibrahim1, Noor Naemah Abdul Rahman2, Shaikh Mohd Saifuddeen3

  • 1Programme of Applied Science with Islamic Studies, Academy of Islamic Studies, University of Malaya, 50603, Kuala Lumpur, Malaysia. ahalim_ibrahim@um.edu.my.

Journal of Bioethical Inquiry
|July 13, 2023
PubMed
Summary
This summary is machine-generated.

Mitochondrial replacement technology (MRT) should not be permitted for Muslims. Concerns include lineage mixing from third-party gametes and uncertain safety, as the aim is conception, not curing mitochondrial DNA disorders.

Keywords:
Assisted reproductionIslamic bioethicsMaqasid al-ShariahMitochondrial replacement therapyTri-parent baby

More Related Videos

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells
11:13

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

Published on: February 22, 2017

12.9K
Rapid Isolation And Purification Of Mitochondria For Transplantation By Tissue Dissociation And Differential Filtration
10:35

Rapid Isolation And Purification Of Mitochondria For Transplantation By Tissue Dissociation And Differential Filtration

Published on: September 6, 2014

38.3K

Related Experiment Videos

Last Updated: Jul 23, 2025

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
06:05

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model

Published on: March 9, 2022

3.8K
MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells
11:13

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

Published on: February 22, 2017

12.9K
Rapid Isolation And Purification Of Mitochondria For Transplantation By Tissue Dissociation And Differential Filtration
10:35

Rapid Isolation And Purification Of Mitochondria For Transplantation By Tissue Dissociation And Differential Filtration

Published on: September 6, 2014

38.3K

Area of Science:

  • Bioethics
  • Genetics
  • Islamic Studies

Background:

  • Mitochondrial replacement technology (MRT) addresses maternal inherited mitochondrial DNA (mtDNA) disorders.
  • The introduction of MRT raises complex bioethical questions, particularly within Islamic jurisprudence.
  • Islamic bioethics, guided by Maqasid al-Shariah, provides a framework for assessing new reproductive technologies.

Purpose of the Study:

  • To analyze and assess tri-parent baby technology using Maqasidic bioethics.
  • To evaluate MRT's implications for the five essential interests in Islam: religion, life, lineage, intellect, and property.
  • To determine the permissibility of MRT for Muslims.

Main Methods:

  • Analysis of tri-parent baby technology through the lens of Maqasidic bioethics.
  • Holistic assessment considering religious, ethical, and safety aspects.
  • Examination of the technology's primary objective versus its therapeutic potential.

Main Results:

  • Tri-parent baby technology raises concerns regarding lineage mixing due to third-party gametes.
  • The safety of MRT is currently uncertain.
  • The primary goal of MRT appears to be enabling affected couples to have genetically healthy children, rather than treating existing mtDNA disorders.

Conclusions:

  • Tri-parent baby technology is not recommended for Muslims based on Maqasidic bioethical principles.
  • Concerns about lineage integrity and safety outweigh the benefits for Muslim communities.
  • The technology's focus on procreation rather than cure necessitates prohibition.