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Related Experiment Video

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Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways

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Low-Dose 0.01% Atropine Eye Drops vs Placebo for Myopia Control: A Randomized Clinical Trial.

Michael X Repka¹, Katherine K Weise², Danielle L Chandler³

¹Wilmer Eye Institute, Baltimore, Maryland.

JAMA Ophthalmology

|July 13, 2023

Summary

Low-dose atropine eye drops did not slow myopia progression in US children. This study found no significant difference in refractive error or axial length changes compared to placebo.

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Published on: February 15, 2022

Area of Science:

Ophthalmology
Pediatric Medicine
Clinical Trials

Background:

Myopia progression is a global concern, with low-dose atropine showing promise in East Asian children.
Effective myopia control strategies are needed for diverse pediatric populations.

Purpose of the Study:

To evaluate the efficacy of 0.01% atropine eye drops in slowing myopia progression in US children.
To compare atropine's effect on refractive error and axial length against a placebo.

Main Methods:

A randomized, double-masked, placebo-controlled trial involving 187 children aged 5-12 years with low to moderate myopia.
Participants received either 0.01% atropine or placebo eye drops nightly for 24 months, followed by a 6-month observation period.
Spherical equivalent refractive error (SER) and axial length were measured by masked examiners.

Main Results:

No significant difference in the change of SER from baseline to 24 months between the atropine (-0.82 D) and placebo (-0.80 D) groups (difference = -0.02 D).
No significant difference in axial length changes at 24 months (atropine: 0.44 mm, placebo: 0.45 mm; difference = -0.002 mm).
Results remained non-significant at the 30-month follow-up for both SER and axial length.

Conclusions:

0.01% atropine eye drops administered nightly did not slow myopia progression or axial elongation in US children with low to moderate myopia.
These findings do not support the use of 0.01% atropine for myopia control in this population.
Further research may be needed to explore different concentrations or populations.