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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

150
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
409
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis II: Collaborative Care01:29

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Related Experiment Video

Updated: Jul 23, 2025

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Drug-Induced Acute Pancreatitis: An Evidence-Based Classification (Revised).

Jasmine Saini1, Daniel Marino, Nison Badalov

  • 1Maimonides Medical Center, State University of New York-Downstate Medical Center, Brooklyn, New York, USA.

Clinical and Translational Gastroenterology
|July 13, 2023
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Summary

Many drugs are incorrectly linked to acute pancreatitis due to weak evidence. This revised classification system uses higher quality studies to accurately identify causative medications, improving diagnosis of drug-induced acute pancreatitis.

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Area of Science:

  • Gastroenterology
  • Clinical Pharmacology

Background:

  • Drug-induced acute pancreatitis diagnosis is challenging.
  • Previous classification systems relied heavily on case reports, leading to misinterpretations.
  • Higher evidentiary value studies are needed for accurate drug-induced acute pancreatitis identification.

Purpose of the Study:

  • To propose a revised, evidence-based classification system for drug-induced acute pancreatitis.
  • To improve the accuracy of identifying causative medications.
  • To utilize the Grading of Recommendations, Development, and Evaluation (GRADE) criteria.

Main Methods:

  • Literature search for medication-induced acute pancreatitis case reports.
  • Categorization of implicated drugs into four groups based on evidence quality.
  • Application of GRADE criteria for evidence assessment.

Main Results:

  • 141 drugs were identified in the literature as potentially causing acute pancreatitis.
  • 106 drugs were supported by high-quality case reports.
  • Only 3 drugs had evidence from randomized controlled trials, including 6-mercaptopurine and azathioprine.

Conclusions:

  • The majority of drugs linked to acute pancreatitis have low-quality evidence.
  • A revised classification system using higher-level evidence is crucial.
  • Accurate identification of causative drugs will improve patient diagnosis and management.