Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

2.6K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.6K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

2.4K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.

Human molecular genetics·2026
Same author

Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn's disease pathogenesis.

Nature genetics·2026
Same author

Cell-type-resolved genetic variation shapes inflammatory bowel disease risk.

Nature·2026
Same author

An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing.

British journal of cancer·2026
Same author

The impossible hustle, sustaining pediatric radiology research amidst clinical demands: insights from a European society of pediatric radiology research committee survey.

Pediatric radiology·2026
Same author

Implementation of pediatric and fetal postmortem imaging into clinical practice: a multi-society statement from the ESPR, SPR, SLARP, AOSPR, WFPI, and IAFR.

Pediatric radiology·2026

Related Experiment Video

Updated: Jul 23, 2025

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands
08:37

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

Published on: October 2, 2018

24.1K

An integrated single-cell analysis of human adrenal cortex development.

Ignacio Del Valle1, Matthew D Young2, Gerda Kildisiute2

  • 1Genetics and Genomic Medicine Research and Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health, UCL, London, United Kingdom.

JCI Insight
|July 13, 2023
PubMed
Summary

Human adrenal gland development involves rapid growth and zone-specific hormone synthesis. This study reveals key transcriptional regulators and gene interactions crucial for understanding adrenal insufficiency and disorders.

Keywords:
DevelopmentEmbryonic developmentEndocrinologyGenetic diseasesTranscription

More Related Videos

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.2K
Confocal Microscopy to Measure Three Modes of Fusion Pore Dynamics in Adrenal Chromaffin Cells
12:30

Confocal Microscopy to Measure Three Modes of Fusion Pore Dynamics in Adrenal Chromaffin Cells

Published on: March 16, 2022

2.2K

Related Experiment Videos

Last Updated: Jul 23, 2025

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands
08:37

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

Published on: October 2, 2018

24.1K
Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.2K
Confocal Microscopy to Measure Three Modes of Fusion Pore Dynamics in Adrenal Chromaffin Cells
12:30

Confocal Microscopy to Measure Three Modes of Fusion Pore Dynamics in Adrenal Chromaffin Cells

Published on: March 16, 2022

2.2K

Area of Science:

  • Developmental Biology
  • Endocrinology
  • Genetics

Background:

  • The adrenal glands produce vital steroid hormones, but human development is poorly understood.
  • Key aspects of early human adrenal gland development require further investigation.

Purpose of the Study:

  • To investigate key aspects of human adrenal gland development during the first 20 weeks of gestation.
  • To identify transcriptional regulators and molecular interactions involved in adrenal development.

Main Methods:

  • Combined single-cell and bulk RNA sequencing.
  • Utilized spatial transcriptomics, immunohistochemistry (IHC), and micro-focus computed tomography.
  • Analyzed gene expression, cell division, and spatial localization.

Main Results:

  • Demonstrated rapid adrenal growth and vascularization, with increased cell division in the definitive zone (DZ).
  • Identified distinct steroidogenic pathway activities between the fetal zone and DZ.
  • Discovered localized expression of HOPX in the DZ and potential ligand-receptor interactions (e.g., RSPO3/LGR4).
  • Found enrichment of growth-promoting imprinted genes (e.g., IGF2, PEG3) in the developing cortex.

Conclusions:

  • Provides novel insights into human adrenal gland development.
  • Highlights the role of specific genes and interactions in adrenal organogenesis.
  • Has implications for understanding primary adrenal insufficiency, adrenal tumors, and neonatal stress.