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Related Concept Videos

Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Related Experiment Video

Updated: Jul 23, 2025

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
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Obesity and Skeletal Fragility.

Rui Chen1,2, Reina Armamento-Villareal1,2

  • 1Division of Endocrinology, Diabetes and Metabolism at Baylor College of Medicine, Houston, TX 77030, USA.

The Journal of Clinical Endocrinology and Metabolism
|July 13, 2023
PubMed
Summary

Obesity and type 2 diabetes mellitus (T2DM) increase fracture risk despite normal bone mineral density (BMD), indicating bone quality issues. Weight loss management may worsen bone health in these patients.

Keywords:
bonefracturesobesitytype 2 diabetes mellitusweight loss

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Bone Biology

Background:

  • Obesity is linked to skeletal fragility, primarily affecting bone quality over quantity, despite normal or high bone mineral density (BMD).
  • Type 2 diabetes mellitus (T2DM), prevalent in obese individuals, independently elevates fracture risk, also with normal or high BMD, suggesting diabetic bone pathology.
  • The combined impact of obesity and T2DM on skeletal health, particularly fracture risk, remains under-investigated, with no current methods for risk identification or prevention.

Conclusions:

  • Patients with obesity and T2DM face a compounded risk of skeletal fragility due to diminished bone quality.
  • Further research is needed to identify high-risk individuals and develop targeted interventions for bone health in this population.
  • Management strategies must consider the potential for bone loss during weight reduction.