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Related Concept Videos

Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

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The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
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Mechanisms of Membrane Domain Formation00:59

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Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
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Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

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Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
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Membrane Fluidity01:23

Membrane Fluidity

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Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
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Related Experiment Video

Updated: Jul 23, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Modulating Lipid Membrane Morphology by Dynamic DNA Origami Networks.

Juanjuan Yang1,2, Kevin Jahnke3, Ling Xin2

  • 1Institute of Molecular Medicine, Department of Laboratory Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200127, People's Republic of China.

Nano Letters
|July 13, 2023
PubMed
Summary

DNA nanotechnology enables precise control over membrane morphology. DNA origami structures reconfigure giant unilamellar vesicles into dynamic networks, modulating synthetic cell functions.

Keywords:
DNA networksDNA origamidynamic DNA nanotechnologygiant unilamellar lipid vesicles (GUVs)membrane curvatureself-assembly

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Synthetic Biology

Background:

  • Membrane morphology and protein dynamics are crucial for cellular functions.
  • DNA nanotechnology offers precise, nanometer-level control for engineering cellular structures.

Purpose of the Study:

  • To demonstrate a DNA origami structure for artificial membrane engineering.
  • To explore the programmable modulation of synthetic cell morphology.

Main Methods:

  • Anchoring DNA origami cross (DOC) structures onto giant unilamellar vesicles (GUVs).
  • Polymerizing DOCs into reconfigurable 1D chains and 2D lattices.
  • Utilizing DNA fuels to switch between left-handed (LH) and right-handed (RH) conformations.

Main Results:

  • Successfully created DNA origami-based networks on GUVs.
  • Demonstrated the ability to form micrometer-scale reconfigurable chains and lattices.
  • Showcased potent efficacy in remodeling GUV membrane curvatures.

Conclusions:

  • Hierarchically assembled dynamic DNA systems can programmatically modulate synthetic cell membranes.
  • DNA origami provides a powerful tool for engineering artificial cellular functions.