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Updated: Jul 23, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Copper-catalyzed N-arylation of amines with aryliodonium ylides in water
Kasturi U Nabar1, Bhalchandra M Bhanage1, Sudam G Dawande2
1Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga East, Mumbai-400019, Maharashtra, India.
Abstract:
Copper sulfate catalyzed an efficient, inexpensive, and environment-friendly protocol that has been developed for N-arylation of amines with 1,3-cyclohexadione-derived aryliodonium ylides in water as a green solvent. Aromatic primary amines substituted with electron-donating as well as electron-withdrawing groups on the aryl ring reacted smoothly with iodonium ylides to give the corresponding diarylamines with good to excellent yields. Also, secondary amines underwent N-arylation to deliver tertiary amines with moderate yields.
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