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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
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Related Experiment Video

Updated: Jul 23, 2025

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis
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Penile Livedoid Vasculopathy: First Reported Case.

Ahmad Hallak1, William Bennett1, Mohammed Adib Tanbir2

  • 1Ochsner Medical Center, New Orleans, Louisiana, USA.

Case Reports in Vascular Medicine
|July 13, 2023
PubMed
Summary
This summary is machine-generated.

Livedoid vasculopathy, a rare condition, was observed for the first time affecting the penis. Apixaban showed significant improvement in penile livedoid vasculopathy, highlighting the need for early diagnosis and treatment.

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Area of Science:

  • Dermatology
  • Vascular Medicine
  • Urology

Background:

  • Livedoid vasculopathy is a rare thromboocclusive disorder typically affecting lower extremities.
  • It presents with characteristic skin changes like livedo reticularis, atrophie blanche, and ulcerations.
  • Pathogenesis is linked to coagulation or impaired thrombolysis, causing dermal vessel occlusion.

Observation:

  • A 60-year-old male presented with penile skin irritation, peeling, and a split urine stream.
  • A non-healing penile ulcer persisted despite initial treatments with steroids and antibiotics.
  • Histopathology confirmed livedoid vasculopathy with hyaline thrombi and fibrinoid material in dermal vessels.

Findings:

  • This is the first reported case of livedoid vasculopathy localized to the penis.
  • Initial treatments with aspirin and pentoxifylline provided limited relief.
  • Apixaban therapy led to near-complete resolution of penile lesions within six months.

Implications:

  • This case expands the known clinical spectrum of livedoid vasculopathy.
  • It underscores the importance of considering livedoid vasculopathy in penile ulcerations of unclear etiology.
  • Prompt diagnosis and targeted anticoagulation therapy, such as with apixaban, are crucial for managing this condition and preventing morbidity.