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Related Experiment Video

Updated: Jul 23, 2025

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
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Flexible, stretchable, and single-molecule-sensitive SERS-active sensor for wearable biosensing applications.

Muhammad Aminul Haque Chowdhury1, Nishat Tasnim1, Mainul Hossain1

  • 1Department of Electrical and Electronic Engineering, University of Dhaka Dhaka-1000 Bangladesh mahabib@du.ac.bd.

RSC Advances
|July 13, 2023
PubMed
Summary

Researchers developed a novel flexible, single-molecule-sensitive sensor using plasmonic metasurfaces. This wearable device achieves an extremely high Raman scattering enhancement factor for advanced remote patient monitoring and personalized medicine.

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Area of Science:

  • Biomedical Technology
  • Materials Science
  • Nanotechnology

Background:

  • Wearable sensors are revolutionizing remote patient monitoring and personalized medicine.
  • Plasmonic metasurfaces enhance Raman scattering signals, showing promise for wearable sensor applications.
  • Developing flexible, sensitive, and easily fabricated metasurfaces remains a significant challenge.

Purpose of the Study:

  • To propose a novel wearable device: a flexible, stretchable, and single-molecule-sensitive surface-enhanced Raman scattering (SERS)-active sensor.
  • To address the long-standing need for high-performance, adaptable metasurfaces in biosensing.
  • To demonstrate a viable platform for advanced personalized medicine and remote health monitoring.

Main Methods:

  • Fabrication of a SERS-active sensor utilizing a polydimethylsiloxane (PDMS) substrate for flexibility.
  • Characterization of the sensor's performance, including its enhancement factor, scattering to absorption ratio, and hotspot volume.
  • Numerical simulations to assess the sensor's reliability under mechanical strain (bending and stretching).

Main Results:

  • Achieved an unprecedented SERS enhancement factor of approximately 1011.
  • Demonstrated a high scattering to absorption ratio (∼2.5) and a large hotspot volume (40 nm × 40 nm × 5 nm).
  • Confirmed reliable SERS performance under bending (up to 100°) and stretching (up to 50%).

Conclusions:

  • The proposed flexible and stretchable SERS sensor offers exceptional sensitivity and performance.
  • Its ease of fabrication and adaptability make it a promising candidate for wearable diagnostic devices.
  • This technology paves the way for advancements in personalized medicine and remote patient monitoring.