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Chimeric Antigen Receptor-T Cell Mediated Bilateral Facial Nerve Palsy: A Case Report
Natalya Patrick1, Nizar Bahlis1,2, Steven Peters1,3
1Cumming School of Medicine, University of Calgary, Calgary, Canada.
The Neurohospitalist
|July 13, 2023
Summary
Chimeric antigen receptor (CAR-T) cell therapy can cause neurotoxicity. This report details a patient experiencing bilateral facial nerve palsy after CAR-T therapy, who fully recovered with steroid treatment.
Area of Science:
- Oncology
- Immunology
- Neuroscience
Background:
- Chimeric antigen receptor (CAR-T) cell therapy shows high efficacy in hematological cancers.
- Immune-mediated side effects, including neurotoxicity, are known complications of CAR-T therapy.
- Immune cell-mediated neurotoxicity syndrome (ICANS) typically presents with cortical symptoms affecting the central nervous system.
