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Cardiac magnetic resonance of hypertrophic heart phenotype: A review
Davide Tore1, Riccardo Faletti1, Clara Gaetani1
1Radiology Unit, Department of Surgical Sciences, AOU Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
Insights
Cardiac magnetic resonance (CMR) aids in diagnosing hypertrophic heart conditions by evaluating left ventricular thickening. This imaging technique helps identify causes and offers prognostic insights for hypertrophic cardiomyopathy.
Area of Science:
- Cardiology
- Medical Imaging
- Genetics
Background:
- Hypertrophic heart phenotype involves abnormal left ventricular (LV) thickening, often as an adaptive response to various conditions.
- Hypertrophic cardiomyopathy (HCM) is a primary genetic cause of cardiac hypertrophy, necessitating the exclusion of other LV hypertrophy causes.
Purpose of the Study:
- To provide a comprehensive overview of Cardiac Magnetic Resonance (CMR) applications in hypertrophic heart phenotype.
- To elucidate the role of CMR in the diagnostic workflow for hypertrophic heart conditions.
Main Methods:
- Cardiac Magnetic Resonance (CMR) offers detailed myocardial evaluation and tissue characterization.
- CMR provides reproducible measurements for assessing ventricular hypertrophy.
Main Results:
- CMR is increasingly utilized to confirm ventricular hypertrophy and identify its underlying causes.
- CMR serves as an effective prognostic tool in managing hypertrophic heart phenotypes.
Conclusions:
- CMR is a valuable imaging modality for diagnosing and assessing hypertrophic heart conditions.
- The integration of CMR enhances the diagnostic workflow and prognostic evaluation of patients with hypertrophic phenotypes.
Abstract:
Hypertrophic heart phenotype is characterized by an abnormal left ventricular (LV) thickening. A hypertrophic phenotype can develop as adaptive response in many different conditions such as aortic stenosis, hypertension, athletic training, infiltrative heart muscle diseases, storage disorders and metabolic disorders. Hypertrophic cardiomyopathy (HCM) is the most frequent primary cardiomyopathy (CMP) and a genetical cause of cardiac hypertrophy. It requires the exclusion of any other cause of LV hypertrophy. Cardiac magnetic resonance (CMR) is a comprehensive imaging technique that allows a detailed evaluation of myocardial diseases. It provides reproducible measurements and myocardial tissue characterization. In clinical practice CMR is increasingly used to confirm the presence of ventricular hypertrophy, to detect the underlying cause of the phenotype and more recently as an efficient prognostic tool. This article aims to provide a detailed overview of the applications of CMR in the setting of hypertrophic heart phenotype and its role in the diagnostic workflow of such condition.
