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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Translational Regulation01:29

Translational Regulation

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Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Alternative RNA Splicing02:18

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Related Experiment Video

Updated: Jul 23, 2025

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells
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Interaction between SIRT1 and non-coding RNAs in different disorders.

Soudeh Ghafouri-Fard1, Hamed Shoorei2,3, Bashdar Mahmud Hussen4

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Genetics
|July 13, 2023
PubMed
Summary
This summary is machine-generated.

Sirtuin 1 (SIRT1) interacts with non-coding RNAs like lncRNAs, miRNAs, and circRNAs. These interactions are crucial in diseases and offer potential therapeutic targets for various disorders.

Keywords:
SIRT1biomarcircRNAlncRNAmiRNA

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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Sirtuin 1 (SIRT1) is a deacetylase enzyme with critical roles in cellular processes.
  • SIRT1 is implicated in the pathogenesis of metabolic diseases, aging, inflammation, and cancer.
  • Non-coding RNAs, including lncRNAs, miRNAs, and circRNAs, are increasingly recognized for their regulatory roles in biological processes.

Purpose of the Study:

  • To review the interactions between SIRT1 and three major classes of non-coding RNAs.
  • To highlight the involvement of these interactions in various pathological conditions.
  • To identify potential therapeutic targets based on SIRT1-non-coding RNA axes.

Main Methods:

  • Literature review of studies investigating SIRT1 and non-coding RNA interactions.
  • Analysis of identified interactions in the context of specific diseases.
  • Summary of known circRNA/miRNA and lncRNA/miRNA pairs involving SIRT1.

Main Results:

  • Multiple lncRNAs, miRNAs, and circRNAs have been identified to interact with SIRT1.
  • These interactions are observed across a wide spectrum of diseases, including cardiovascular diseases, metabolic disorders, and cancers.
  • Synergistic interactions between different non-coding RNAs and SIRT1 have been documented.

Conclusions:

  • Non-coding RNAs play significant roles in modulating SIRT1 activity and function.
  • SIRT1-non-coding RNA regulatory axes represent promising targets for novel therapeutic strategies.
  • Further research into these interactions could lead to advancements in treating diverse human diseases.