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Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study.
Han Zhang1,2, Shuai Yuan3, Yong Li4
1Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, China.
Frontiers in Medicine
|July 13, 2023
Summary
This study found a two-way causal link between atopic dermatitis and chronic kidney disease (CKD). Genetic links suggest that having atopic dermatitis increases CKD risk, and vice versa.
Area of Science:
- Genetics
- Epidemiology
- Nephrology
Background:
- Observational studies suggest a link between atopic dermatitis and chronic kidney disease (CKD), but causality remains unclear.
- Atopic dermatitis, a common inflammatory skin condition, affects millions globally.
- Chronic kidney disease (CKD) is a progressive loss of kidney function.
Purpose of the Study:
- To investigate the bidirectional causal relationship between atopic dermatitis and CKD using Mendelian randomization.
- To leverage genetic predisposition to infer causality between these two conditions.
Main Methods:
- Utilized Mendelian randomization, a method employing genetic variants as instrumental variables.
- Selected independent genetic instruments for atopic dermatitis and CKD from large-scale genome-wide association studies.
- Employed inverse-variance weighted method for primary analysis, with sensitivity analyses to ensure robustness.
Main Results:
- A genetic predisposition to atopic dermatitis was significantly associated with an increased risk of CKD (OR 1.07, 95% CI 1.01-1.12).
- Conversely, a genetic predisposition to CKD was associated with an increased risk of atopic dermatitis (OR 1.14, 95% CI 1.03-1.26).
- Sensitivity analyses confirmed these bidirectional associations, with no evidence of pleiotropy.
Conclusions:
- This Mendelian randomization study provides evidence for a bidirectional causal association between atopic dermatitis and CKD.
- The findings suggest that interventions targeting atopic dermatitis may impact CKD risk, and vice versa.
Keywords:
MR-PRESSOMendelian randomizationatopic dermatitisbidirectional Mendelian randomizationchronic kidney diseaseMore Related Videos
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